Mega Detox (Ingredients & Clinical Studies)
Sodium Chlorite
American Chemistry Council
Sodium Chlorite / Chlorine Dioxide
- NIH - National Library of Medicine (National Center for Biotechnology Information)
- PMC - PubMed Central
- EHP - Environmental Health
Perspectives
Controlled clinical evaluations of chlorine dioxide, chlorite and chlorate in man.
Ascorbic Acid
Clinical studies on ascorbic acid
Based on the provided search results, here are some key findings from clinical studies on ascorbic acid:
Cardiovascular Disease: Studies have shown that oral administration of ascorbic acid reduces blood pressure and increases endothelial function in patients with cardiovascular disease (CVD) [1, 2]. Low plasma levels of ascorbic acid have been linked to an increased risk of CVD in men and women [3].
Cancer: High-dose intravenous administration of ascorbic acid has been well-tolerated in advanced cancer patients, with a recommended dose of 70-80 g/m2 [4]. Ascorbic acid has also been shown to have immune-stimulating effects and has been used as an adjunct chemotherapeutic agent in various types of cancer [5].
Wound Healing: Ascorbic acid supplementation (500 mg twice daily) has been found to be effective in promoting wound healing in patients with pressure ulcers [6].
Abdominal Aortic Aneurysm Repair: A randomized clinical trial found that a single bolus dose of intra-operative parenteral ascorbic acid (2g) attenuated biomarkers of ischaemia-reperfusion injury in patients undergoing elective open abdominal aortic aneurysm repair [7].
Tables and Studies
- Table 1: Ascorbic acid content in fruit and vegetables [8]
- Table 3: Randomized clinical studies in cancer patients treated with ascorbic acid [9]
- Table 4: Clinical trials and meta-analysis based on the immune-stimulating effects of ascorbic acid [10]
- Study: “A randomized clinical trial of ascorbic acid in open abdominal aortic aneurysm repair” [7]
- Study: “Randomized clinical trial of ascorbic acid in the treatment of pressure ulcers” [6]
Clinical pharmacological aspects of ascorbic acid
Boron
Summarized boron-based treatment outcomes from published clinical trials.
Based on the available information, here are the key findings:
Acute supplementation: A study found that a single dose of 11.6 mg boron resulted in a significant increase in plasma boron concentration, indicating rapid bioavailability.
Daily vs. weekly supplementation: Another study compared the effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. The results showed that both daily and weekly supplementation had similar effects, with significant increases in plasma boron concentration and improvements in hormone levels and inflammatory markers.
Anti-inflammatory effects: Boron-based supplements, such as calcium fructoborate, have been shown to effectively reduce inflammation in both animal and human studies, with negligible side effects. In vitro studies have also demonstrated antioxidant and anti-inflammatory properties of calcium fructoborate.
Improvement rates: A double-blind, placebo-controlled study found that 50% of subjects taking boron supplements showed improvement, compared to only 10% of the placebo group.
Boron
https://ods.od.nih.gov/factsheets/Boron-HealthProfessional/
https://medlineplus.gov/druginfo/natural/894.html
Zeolite
Clinical studies on zeolite
Based on the provided search results, here is a summary of the clinical studies on zeolite:
Detoxification and Heavy Metal Removal: Several studies suggest that zeolite supplementation can help reduce concentrations of heavy metals such as mercury (Hg), cadmium (Cd), arsenic, nickel (Ni), and aluminum (Al) in the blood. A 28-day clinical trial showed decreased concentrations of Hg and Cd in the treatment group. Another study observed statistically significant improvements in blood arsenic levels after 12 weeks of supplementation.
Mineral Balance and Homeostasis: Long-term studies suggest that zeolite supplementation may affect the homeostasis of calcium and other minerals involved in ion exchange. This may be important to consider when using zeolite for extended periods.
Clinical Trials: Three clinical trials were conducted using a registered and certified clinoptilolite material (PMA-zeolite). The studies included:
- Short-term (28 days): Mineral Metabolism and selected Blood Parameters study (MMBP)
- Medium-term (12 weeks): Morbus Crohn study
- Long-term (4 years): Osteoporosis TOP study
Safety and Efficacy: The clinical trials demonstrated the safety and efficacy of PMA-zeolite supplementation in various patient populations. The dosage was adjusted according to certification and EFSA safety data.
Other Effects: Zeolite has been shown to have antioxidant, immunostimulatory, antidiarrheal, bone-protective, and anti-tumor effects in preclinical studies. However, its usage in humans has not been comprehensively evaluated in detail within large controlled clinical studies until these recent trials.
The Latest Clinical Research on Zeolite and Heavy Metal Detoxification
Zeolite Clinoptilolite: Therapeutic Virtues of an Ancient Mineral
Activated Charcoal
Clinical studies on activated charcoal
Mechanisms of Action: Recent studies suggest that activated charcoal’s mechanisms of action include “back diffusion” and disruption of enterohepatic loops, enhancing its effectiveness in treating poisoned patients.
Single Most Effective Treatment: Some studies indicate that activated charcoal may be the single most effective treatment in many types of poisoning, surpassing gastric emptying as the primary treatment approach.
Pharmacokinetics: A 1982 study by Neuvonen PJ examined the clinical pharmacokinetics of oral activated charcoal in acute intoxications, providing valuable insights into its absorption and elimination rates.
Effectiveness in Specific Conditions: Research has shown that activated charcoal may be beneficial in treating:
- Gas and indigestion: Some studies demonstrate its ability to alleviate symptoms, while others have mixed results.
- Leg ulcers: Activated charcoal in bandages has been shown to aid in healing and reduce odors associated with infections.
- Skin conditions: Charcoal-based creams and washes may help clear acne, although results are inconsistent.
Limitations and Contradictions: Activated charcoal may not be effective in clearing certain substances from the body, such as acid, iron, lithium, alcohols, alkali, or toxins in gasoline. Additionally, some studies have mixed results on its ability to lower cholesterol levels or treat ulcers and bedsores.
Factors Influencing Efficacy: A 2019 review highlighted several factors that can impact the clinical efficacy of activated charcoal, including:
- Dose and administration route
- Timing of administration
- Type and amount of substance ingested
- Presence of other medications or substances
Overall, while activated charcoal has shown promise in various clinical settings, its effectiveness can vary depending on the specific condition, substance, and circumstances. Further research is needed to fully understand its mechanisms and optimal uses.
